The Operating System for N-of-1 Manufacturing
Electron Bio is leading a national effort to build the ARPA-H GIVE Network. We are creating a flexible, AI-driven, and distributable platform to transform personalized genetic medicines from a 10-year challenge into a <3-month reality.
The Integration Problem: Why N-of-1 is Still Out of Reach
The N-of-1 manufacturing challenge isn't a science problem—it's an integration problem.
Today's biomanufacturing systems are rigid, slow, and expensive. They are purpose-built for a single drug, making them impossible to adapt. You cannot have a flexible "N-of-1" solution if you need an entirely new facility for every "N."
The GIVE program requires a new approach. It demands a platform that is flexible by design, digitally native, and modality-agnostic.
Our Solution: A Flexible, Open-Architecture Network
The "Body" The FAST GMP™ Architecture
This is our "hardware" model: a Flexible, Agile, Scalable, and Technology-driven network. We are not building a single, monolithic factory. We are building a network of cloneable, modular manufacturing pods based on "islands of automation."
The "Brain" The Cerebex OS™
This is the "brain" of the entire network. The Cerebex OS is our 21 CFR 11-compliant, AI-driven digital platform (PQS/MES/LIMS). It is the operating system that seamlessly integrates all hardware, automates quality review, and enables remote expert execution.
Our Architecture: "Islands of Automation"
Our platform is an open-architecture "motherboard" designed to integrate any best-in-class technology. We are the Lead System Integrator that connects and controls modules built by Electron Bio or externally.
Figure 1: The Network Integrator: This figure shows how the Cerebex OS is the central "brain" that connects TA1 (Manufacturing) and TA2 (QC).
Figure 2: Islands of Automation: This figure shows our "plug-and-play" model. The Cerebex™ OS is the digital backbone that allows modular "islands" for any technology—Cell-Free DNA, ASO/gRNA Synthesis, RNA Production, or LNP Formulation—to be integrated, qualified, and run by the same system.
We Are Building the Network. Build it With Us.
The Cerebex™ OS is an open platform. We are actively seeking best-in-class partners to plug into our ecosystem. If you are a leader in the following areas, we want to talk to you.
Next-Gen Synthesis We are seeking enzymatic and aqueous-phase ASO/gRNA platforms.
Advanced PAT & Automation We need in-line sensors (MS, Raman, DLS) and GAMP-5 compliant module fabricators.
AI & Digital Innovators We are looking for GxP-compliant AI/ML firms to co-develop validated agents and code for the Cerebex™ OS.
Novel Modality Platforms We want to integrate your saRNA, circRNA, and other novel platforms to prove the universal power of our network.
True Innovators - we want to include the most innovative but practically solutions possible, if you fit that mold contact us.